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http://www.apple.com/iphone/how-to/#basics.cleaning-iphone
Cleaning iPhone
To clean iPhone, unplug all cables and turn off iPhone (press and hold the Sleep/ Wake button, then slide the onscreen slider). Then use a soft, slightly damp, lint-free cloth. Avoid getting moisture in openings. Don’t use window cleaners, household cleaners, aerosol sprays, solvents, alcohol, ammonia, or abrasives to clean iPhone. If your iPhone has an oleophobic coating on the screen (iPhone 3G S only), simply wipe your iPhone’s screen with a soft, lint-free cloth to remove oil left by your hands and face.